C-reactive protein in type 2 diabetes and denture stomatitis


Nejat Düzgüneş: 0000-0001-6159-1391


Biomedical Sciences

Document Type

Conference Presentation

Conference Title

International Association for Dental Research (IADR)/Annual Meeting of the American Association for Dental Research (AADR) General Session and Exhibition


San Diego, CA

Conference Dates

March 16-19, 2011

Date of Presentation



Objectives: Candida-associated denture stomatitis (CaDS), is a common disease in complete denture wearers with type 2 diabetes mellitus (T2DM). C-reactive protein (CRP), an acute phase reactant is a sensitive marker of inflammation associated with diabetes. The aim of this study was to determine the concentrations of CRP in patients with T2DM and CaDS, and investigate the relationship between CRP concentrations and glycated hemoglobin A1c (HbA1c) levels, which was used as an indicator of glycemic control. Materials and Methods: The study involved 110 T2DM patients (63 women and 47 men, mean age 63.2±10.5 years) with CaDS, and 20 patients (12 women and 8 men, mean age 65.8±12.9 years), with T2DM and healthy oral mucosa. A group of 20 non-diabetics (11 women and 9 men, mean age 59.2±9.9 years) with healthy oral mucosa served as a control. The yeasts were isolated by the culture method, and identified by microscopic examination and with the test kit, ID 32 C (bioMerieux SA, Marcy-l'Etoile, France). Serum concentrations of CRP were determined by rocket immunoelectrophoresis according to Laurell. Glycemic control was evaluated by measuring HbA1c levels using HPLC together with the Variant Hemoglobin A1c Program (Bio-Rad Laboratories, Hercules CA, USA). Results: The mean duration of diabetes was 10.6±5.1 years, and the mean HbA1c levels in T2DM subjects were 8.6 ±1.9%. Patients with T2DM had significantly elevated mean levels of CRP in comparison to patients with normal glucose metabolism (6.12±2.86 vs 2.57±0.96 mg/l, p<0.05). The highest CRP levels were observed in diabetics with type II (Newton classification) CaDS (8.39±2.70 mg/l). A positive correlation was found between the concentrations of CRP and fasting plasma glucose levels (rS=0.517, p<0.001) and HbA1c levels (rS=0.572, p<0.001). Conclusions: The findings suggest that CRP concentrations can be used as a non-specific indicator of ongoing inflammation in patients with T2DM.

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