Department
Biomedical Sciences
Document Type
Article
Publication Title
Frontiers in Neurology
ISSN
1664-2295
Volume
12
DOI
10.3389/fneur.2021.654739
First Page
654739
Publication Date
6-7-2021
Abstract
The current treatments for neurodegenerative diseases are mostly symptomatic without affecting the underlying cause of disease. Emerging evidence supports a potential role for immunotherapy in the management of disease progression. Numerous reports raise the exciting prospect that either the immune system or its derivative components could be harnessed to fight the misfolded and aggregated proteins that accumulate in several neurodegenerative diseases. Passive and active vaccinations using monoclonal antibodies and specific antigens that induce adaptive immune responses are currently under evaluation for their potential use in the development of immunotherapies. In this review, we aim to shed light on prominent immunotherapeutic strategies being developed to fight neuroinflammation-induced neurodegeneration, with a focus on innovative immunotherapies such as vaccination therapy.
Recommended Citation
Mortada, I.,
Farah, R.,
Nabha, S.,
Ojcius, D. M.,
Fares, Y.,
Almawi, W. Y.,
&
Sadier, N. S.
(2021).
Immunotherapies for Neurodegenerative Diseases.
Frontiers in Neurology, 12, 654739.
DOI: 10.3389/fneur.2021.654739
https://scholarlycommons.pacific.edu/dugoni-facarticles/732
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
