Photodynamic therapy of Porphyromonas gingivalis via liposome-encapsulated sensitizers
Nejat Düzgüneş: 0000-0001-6159-1391
Journal of the California Dental Association
Photodynamic therapy exploits the light-activation of a photosensitizer to cause cytotoxicity. Liposomes can be used to deliver hydrophobic photosensitizers to bacteria. Positively charged dioleoyltrimethylammoniumpropane:palmitoyloleoylphosphatidylcholine (1:1) liposomes bound quantitatively to the periodontal pathogen, Porphyromonas gingivalis. Following illumination, free and liposomal zinc phthalocyanine reduced the colony-forming unit (CFU) to 65 percent and 23 percent of controls, respectively. Thus, localization of the photosensitizer at the surface of bacteria via liposome binding enhanced the photodynamic cytotoxicity of zinc phthalocyanine.
Photodynamic therapy of Porphyromonas gingivalis via liposome-encapsulated sensitizers.
Journal of the California Dental Association, 41(11), 827–830.