ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
BioMed Research International
ISSN
2314-6133
Volume
2020
DOI
10.1155/2020/5764017
Publication Date
1-1-2020
Abstract
Sleep plays an important role in maintaining neuronal circuitry, signalling and helps maintain overall health and wellbeing. Sleep deprivation (SD) disturbs the circadian physiology and exerts a negative impact on brain and behavioural functions. SD impairs the cellular clearance of misfolded neurotoxin proteins like α-synuclein, amyloid-β, and tau which are involved in major neurodegenerative diseases like Alzheimer's disease and Parkinson's disease. In addition, SD is also shown to affect the glymphatic system, a glial-dependent metabolic waste clearance pathway, causing accumulation of misfolded faulty proteins in synaptic compartments resulting in cognitive decline. Also, SD affects the immunological and redox system resulting in neuroinflammation and oxidative stress. Hence, it is important to understand the molecular and biochemical alterations that are the causative factors leading to these pathophysiological effects on the neuronal system. This review is an attempt in this direction. It provides up-to-date information on the alterations in the key processes, pathways, and proteins that are negatively affected by SD and become reasons for neurological disorders over a prolonged period of time, if left unattended.
Recommended Citation
Bishir, M.,
Bhat, A.,
Essa, M.,
Ekpo, O.,
Ihunwo, A. O.,
Veeraraghavan, V.,
Mohan, S.,
Mahalakshmi, A. M.,
Ray, B.,
Tuladhar, S.,
Chang, S.,
Chidambaram, S.,
Sakharkar, M.,
Guillemin, G. J.,
Qoronfleh, M. W.,
&
Ojcius, D. M.
(2020).
Sleep Deprivation and Neurological Disorders.
BioMed Research International, 2020,
DOI: 10.1155/2020/5764017
https://scholarlycommons.pacific.edu/dugoni-facarticles/517
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
