ORCiD
David M. Ojcius: 0000-0003-1461-4495; Cassio Almeida-da-Silva: 0000-0001-9173-7208
Department
Biomedical Sciences
Document Type
Article
Publication Title
Biomedical Journal
ISSN
2320-2890
Volume
42
Issue
1
DOI
10.1016/j.bj.2018.12.001
First Page
27
Last Page
35
Publication Date
1-31-2019
Abstract
A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease.
Recommended Citation
Bui, F. Q.,
Almeida-da-Silva, C. L.,
Huynh, B.,
Trinh, A.,
Liu, J.,
Woodward, J.,
Asadi, H.,
&
Ojcius, D. M.
(2019).
Association between periodontal pathogens and systemic disease.
Biomedical Journal, 42(1), 27–35.
DOI: 10.1016/j.bj.2018.12.001
https://scholarlycommons.pacific.edu/dugoni-facarticles/456
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
