Title

Immunomodulatory Properties of Plants and Mushrooms

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Trends in Pharmacological Sciences

ISSN

1873-3735

Volume

38

Issue

11

DOI

10.1016/j.tips.2017.07.006

First Page

967

Last Page

981

Publication Date

11-1-2017

Abstract

Plants and mushrooms are used for medicinal purposes and the screening of molecules possessing biological activities. A single plant or mushroom may produce both stimulatory and inhibitory effects on immune cells, depending on experimental conditions, but the reason behind this dichotomy remains obscure. We present here a large body of experimental data showing that water extracts of plants and mushrooms usually activate immune cells, whereas ethanol extracts inhibit immune cells. The mode of extraction of plants and mushrooms may thus determine the effects produced on immune cells, possibly due to differential solubility and potency of stimulatory and inhibitory compounds. We also examine the possibility of using such plant and mushroom extracts to treat immune system disorders.

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