ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Emerging Microbes and Infections

ISSN

2222-1751

Volume

7

Issue

1

DOI

10.1038/s41426-018-0135-9

First Page

1

Last Page

17

Publication Date

7-31-2018

Abstract

Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. interrogans caused apoptosis of phagocytosis-inhibited macrophages, and the product of the L. interrogans LB047 gene (Lep-OMP047) was the unique protein captured by mouse and human Fas proteins. The recombinant expressed Lep-OMP047 (rLep-OMP047) strongly bound mouse and human Fas proteins with equilibrium association constant (K

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Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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