ORCiD
David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Emerging Microbes and Infections
ISSN
2222-1751
Volume
7
Issue
1
DOI
10.1038/s41426-018-0135-9
First Page
1
Last Page
17
Publication Date
7-31-2018
Abstract
Leptospira interrogans is the major causative agent of leptospirosis, an emerging, globally spreading zoonotic infectious disease. The pathogen induces macrophage apoptosis, but the molecular basis and mechanism remain unknown. In the present study, we found that L. interrogans caused apoptosis of phagocytosis-inhibited macrophages, and the product of the L. interrogans LB047 gene (Lep-OMP047) was the unique protein captured by mouse and human Fas proteins. The recombinant expressed Lep-OMP047 (rLep-OMP047) strongly bound mouse and human Fas proteins with equilibrium association constant (K
Recommended Citation
Du, P.,
Li, S.,
Ojcius, D. M.,
Li, K.,
Hu, W.,
Lin, X.,
Sun, A.,
&
Yan, J.
(2018).
A novel Fas-binding outer membrane protein and lipopolysaccharide of Leptospira interrogans induce macrophage apoptosis through the Fas/FasL-caspase-8/-3 pathway..
Emerging Microbes and Infections, 7(1), 1–17.
DOI: 10.1038/s41426-018-0135-9
https://scholarlycommons.pacific.edu/dugoni-facarticles/433
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
