At the innate frontiers between mother and fetus: linking abortion with complement activation

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Department

Biomedical Sciences

Document Type

Article

Publication Title

Immunity

ISSN

1074-7613

Volume

18

Issue

2

DOI

10.1016/S1074-7613(03)00028-1

First Page

169

Last Page

172

Publication Date

2-1-2003

Abstract

The intricate mechanisms regulating fetomaternal interactions are still largely uncharacterized. Recent papers have revealed a major role for the innate immune system during abortion. Different experimental conditions—deletion of a complement regulator, injection of anti-phospholipid antibodies into mothers, or allorecognition of fetuses in the presence of an IDO inhibitor—all lead to complement activation, inflammation, and fetal loss. These observations also raise new questions on the relationship between the adaptive and innate systems during pregnancy.

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