NMR investigation of phospholipid/PEG-ceramide-liposomes
241st American Chemical Society (ACS) National Meeting & Exposition
American Chemical Society (ACS)
March 27-31, 2011
Date of Presentation
Liposomes are macromolecular structures in which an aqueous core is surrounded by a double-layered lipid membrane. Surface modifications in liposomes serve the purpose of enhanced water-solubility, immuno-compatibility, and targeted delivery of liposome “cargo”, e.g. drugs or DNA/RNA. Liposomal drug delivery systems are frequently composed of phospho-lipids and ceramides amongst others. We investigated pH-sensitive liposomes. Complete NMR structure assignment and quantification of all components provided quality control. During liposome extrusion/preparation/loading and cleanup, little to no variation in composition was observed.
Franz, A. H.,
Samoshina, N. M.,
Samoshin, V. V.
NMR investigation of phospholipid/PEG-ceramide-liposomes.
Paper presented at 241st American Chemical Society (ACS) National Meeting & Exposition in Anaheim, CA.