Title

Interleukin-1Beta and Dentistry

Poster Number

25

Lead Author Affiliation

Dugoni School of Dentistry, Orthodontics

Additional Authors

Miroslav Tolar and Marie M. Tolarova

Introduction

Interleukin–1beta (IL-1b) is a potent cytokine that enhances local inflammatory response through binding to different types of local target cells. It facilitates differentiation of monocytes into multinucleated osteoclasts and thus enhances bone resorption. Many studies concluded that IL-1b is a strong inducer of connective tissue degradation in general. IL-1b seems to play a major role in immune reactions occurring in dental and orofacial tissues.

Purpose

We reviewed the current knowledge related to behavior of IL-1b in oral and dental diseases and adaptations.

Method

Relevant recent articles were reviewed and the new information was combined with the previous knowledge.

Results

IL-1b and PERIODONTAL DISEASE: Studies have shown that lipopolysaccharides (LPS) present on the outer membrane of gram negative bacteria causing periodontal disease induce secretion of IL-1b that starts innate and adaptive inflammatory responses. Further studies have suggested that both probing depth (PD) and attachment loss (AL) are strongly correlated with IL-1b levels in gingival crevicular fluid (GCF). When patients with different severity degrees of periodontal disease were compared, it was found that patients with a more severe disease tend to have higher levels of IL-1b in GCF than those with a moderate or mild disease regardless of the PD value of the examined site. IL-1b and ORTHODONTIC TOOTH MOVEMENT: When mechanical force is applied on a tooth, a localized sterile tissue innate inflammatory response takes place. One of the first signs is secretion of IL-1b. Levels of IL-1b in GCF were found to peak after 24 hours of force application. A second peak of IL-1b levels was found 24 hours after re-activation of the applied force. These findings suggest that time scale of IL-1b secretion may be a good guide for timely controlled applications of force and reactivations during orthodontic treatment.

Significance

A better understanding of biology and physiology of IL-1b-related pathways might open the way for future improvement and/or customization of dental treatment plans.

Location

DeRosa University Center, Stockton campus, University of the Pacific

Format

Poster Presentation

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Apr 25th, 2:00 PM Apr 25th, 4:00 PM

Interleukin-1Beta and Dentistry

DeRosa University Center, Stockton campus, University of the Pacific

Interleukin–1beta (IL-1b) is a potent cytokine that enhances local inflammatory response through binding to different types of local target cells. It facilitates differentiation of monocytes into multinucleated osteoclasts and thus enhances bone resorption. Many studies concluded that IL-1b is a strong inducer of connective tissue degradation in general. IL-1b seems to play a major role in immune reactions occurring in dental and orofacial tissues.