Nonsteroidal antiinflammatory drugs: Review of factors guiding formulary considerations

ORCiD

0000-0002-5447-9016

Document Type

Article

Publication Title

Formulary

ISSN

1082-801X

Volume

35

Issue

2

First Page

142

Last Page

168

Publication Date

2-1-2000

Abstract

The selection and use of nonsteroidal anti-inflammatory drugs (NSAIDs) is complicated by the introduction of new products and formulations and the emergence of additional information on older products. Numerous NSAIDs are now available by prescription and/or over the counter and are indicated for use in a variety of inflammatory, pain, and other disorders (table 1).

In general, all NSAIDs are equivalent in efficacy for their approved indications,[1-14] but they may differ in acquisition cost, dosage form, dosing interval, and the occurrence and severity of adverse effects, overdose, and drug interactions. Approved indications, studies of off-label uses, and data on protection against specific diseases or NSAID-induced adverse effects in select populations provide further information for formulary decision-making. This article provides an overview and analysis of available clinical data to aid in the optimal selection of systemic NSAIDs for general or specific patient populations.

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