ORCiD
Cassio Almeida-da-Silva: 0000-0001-9173-7208; David M. Ojcius: 0000-0003-1461-4495
Department
Biomedical Sciences
Document Type
Article
Publication Title
Frontiers in Immunology
ISSN
1664-3224
Volume
14
DOI
10.3389/fimmu.2023.1122586
First Page
1
Last Page
11
Publication Date
3-15-2023
Abstract
The innate immune system in vertebrates and invertebrates relies on conserved receptors and ligands, and pathways that can rapidly initiate the host response against microbial infection and other sources of stress and danger. Research into the family of NOD-like receptors (NLRs) has blossomed over the past two decades, with much being learned about the ligands and conditions that stimulate the NLRs and the outcomes of NLR activation in cells and animals. The NLRs play key roles in diverse functions, ranging from transcription of MHC molecules to initiation of inflammation. Some NLRs are activated directly by their ligands, while other ligands may have indirect effects on the NLRs. New findings in coming years will undoubtedly shed more light on molecular details involved in NLR activation, as well as the physiological and immunological outcomes of NLR ligation.
Recommended Citation
Almeida-Da-Silva, C. L.,
Savio, L. E.,
Coutinho-Silva, R.,
&
Ojcius, D. M.
(2023).
The role of NOD-like receptors in innate immunity.
Frontiers in Immunology, 14, 1–11.
DOI: 10.3389/fimmu.2023.1122586
https://scholarlycommons.pacific.edu/dugoni-facarticles/851
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
