Title

Danger signals, inflammasomes, and the intricate lives of chlamydiae

ORCiD

David M. Ojcius: 0000-0003-1461-4495

Document Type

Article

Publication Title

Biomedical Journal

ISSN

2319-4170

Volume

39

Issue

5

DOI

10.1016/j.bj.2016.07.001

First Page

306

Last Page

315

Publication Date

10-1-2016

Abstract

Chlamydiae are obligate intracellular bacterial pathogens, and as such are sensitive to alterations in the cellular physiology of their hosts. Chlamydial infections often cause pathologic consequences due to prolonged localized inflammation. Considerable advances have been made in the last few years regarding our understanding of how two key inflammation-associated signaling pathways influence the biology of Chlamydia infections: inflammation regulating purinergic signaling pathways significantly impact intracellular chlamydial development, and inflammasome activation modulates both chlamydial growth and infection mediated pro-inflammatory cytokine production. We review here elements of both pathways, presenting the latest developments contributing to our understanding of how chlamydial infections are influenced by inflammasomes and purinergic signaling.