Title

Luciferase gene transfection mediated by cationic liposomes comprising novel trans-2-aminocyclohexanol-based amphiphiles

Document Type

Poster

Department

Chemistry

Conference Title

243rd American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

San Diego, CA

Conference Dates

March 25-March 29, 2012

Date of Presentation

3-28-2012

Abstract

Incorporation of trans-2-aminocyclohexanol-based amphiphiles as helper lipids in DOTAP-cationic liposomes enhances substantially the transfection of the Gaussia luciferase plasmid into HeLa and B16F1 cells. The efficiency of transfection strongly depends on the structure of lipophilic chains and NRR' groups.

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