Title

Fliposomes: Stimuli-triggered conformational flip of novel amphiphiles causes an instant cargo release from liposomes

Document Type

Conference Presentation

Department

Chemistry

Conference Title

248th American Chemical Society (ACS) National Meeting

Organization

American Chemical Society (ACS)

Location

San Francisco, CA

Conference Dates

August 10-14, 2014

Date of Presentation

8-11-2014

Abstract

New developments are presented in the design of stimuli-responsive liposomes for targeted delivery via the construction of a liposome membrane (lipid bilayer) using amphiphiles able to perform a stimuli-triggered conformational flip (“flipids”). When done simultaneously by a major or significant part of the bilayer molecules, this massive flip disrupts the liposome membrane and induces a rapid release of the liposome load specifically in response to the initial stimulus. The conformational switches incorporated into the amphiphilic molecules could potentially be controlled by various internal or external factors (pH, metal complexation, light, etc.). Using this concept we designed a series of pH-triggerable “flipids”, and prepared and tested “fliposomes” with extraordinary characteristics: high stability in storage and in serum combined with an instant release of their cargo in response to a weakly acidic medium.

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