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Date of Award


Document Type

Dissertation - Pacific Access Restricted

Degree Name

Doctor of Philosophy (Ph.D.)


Graduate School

First Advisor

Patrick N. Catania

First Committee Member

Arthur F. Harralson

Second Committee Member

Katherine K. Knapp

Third Committee Member

Michael A. Mergener

Fourth Committee Member

Fuad M. Nahhas


The purpose of this research was to investigate home intravenous antibiotic therapy (HIVAT) in a multicenter, retrospective study in 1986 and 1987. The stability of reconstituted ceftizoxime and cefonicid in normal saline were evaluated by HPLC to investigate their usability for HIVAT. Using the three HHCPs' records, 457 patients were screened, and 30 patients were randomly selected/HHCP/year using the study's inclusion criteria (n = 180). Outcomes of HIVAT for osteomyelitis patients (n = 90) were compared with that for osteomyelitis inpatients (n = 13) discharged to HHCP1 from the referral hospital. Outcomes were classified as "success", "complication", and "failure". Types and frequency of problems were categorized as problems with antibiotics, and problems with administration procedures. Demographic data were analyzed to test the homogeneity of each group of patients. Data were analyzed using ANOVA, chi-square test, Kruskal-Wallis test, and multiple comparisons among proportions. (Abstract shortened with permission of author.)



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