Date of Award
1973
Document Type
Dissertation
Degree Name
Doctor of Philosophy (Ph.D.)
Department
Pharmacy
First Advisor
James King
First Committee Member
George R. Herron
Second Committee Member
Howell Runion
Third Committee Member
Madhukar G. Chaubal
Fourth Committee Member
Donald Y. Barker
Fifth Committee Member
David Wolter
Abstract
Numerous investigators have noted that individuals vary widely in their response to the anticoagulant, heparin. Animal model3 have suggested that patients with depressed renal function would be expected to clear heparin from the blood at a slower rate than patients with normal renal function.
Utilizing the Activated Coagulation Time clotting test, a method was developed to determine the anticoagulant half-life of heparin. The study calculated the half-life of heparin in a group of individuals with normal renal function and a population of patients in chronic renal failure. Intravenous heparin doses of 0,3 units/ml and 0.6 units/ml of blood were administered to the subjects in the study.
The anticoagulant half-life of heparin was found to be a dose related phenomenon. The normal renal function group gave a mean heparin anticoagulant half-life of 37«13 minutes for the 0.6 unit/ml dose while It yielded a mean half-life of 22.70 minutes for the 0.3 unit/ml dose. The chronic renal failure population produced a mean half-life of lj.2.27 minutes for the 0.6 unit/ml dose while the 0.3 unit/ml dose gave a mean half-life of 32.07 minutes.
At the 0.3 unit/ml heparin blood level, a significant difference was found to exist between the half-life determinations of the normal renal function group and the chronic renal failure group. However, a significant difference in the half-life determinations was not observed between the two populations at the 0.6 unit/ml heparin blood level.
An increase in the effect of heparin was observed in the renal failure patients. This increase was more pronounced at the 0.3 unit/ml blood level than at the 0.6 unit/ml blood level.
By use of the equations of first order pharmacokinetics a heparin dosage schedule was arrived through which a rational approach to heparinization of patients can proceed through the utilization of a constant infusion pump. The schedule is not only applicable for patients in renal failure but also may be utilized in heparinization of patients with normal renal function.
Pages
116
Recommended Citation
Perry, Paul James. (1973). Anticoagulant Half-Life Of Heparin In Human Subjects With Normal And Impaired Renal Function.. University of the Pacific, Dissertation. https://scholarlycommons.pacific.edu/uop_etds/3301
Included in
Environmental Health Commons, Other Pharmacology, Toxicology and Environmental Health Commons, Pharmacy and Pharmaceutical Sciences Commons
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