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Date of Award


Document Type


Degree Name

Doctor of Philosophy (Ph.D.)


Graduate Studies

First Advisor

James C. King

First Committee Member

Donald Y. Barker

Second Committee Member

Madhukar G. Chaubal

Third Committee Member

Warren J. Schneider

Fourth Committee Member

Fuad M. Nahhas


Local burn therapy usually includes the application of medicated ointments and dressings in order to minimize and eradicate infection. As this approach to local therapy may present problems regarding application and removal techniques, it was the purpose of this study to formulate a topical dosage form that may be applied to denuded areas of the skin without inunction. Using the concept of topical films, a dosage form was formulated that is highly water soluble, flexible , and adherent to both denuded and intact areas of the skin.