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Date of Award


Document Type


Degree Name

Doctor of Philosophy (Ph.D.)


Graduate School

First Advisor

Marvin Malone

First Committee Member

Donald Shiachi

Second Committee Member

Francis Sayre

Third Committee Member

Carl C. Riedesel

Fourth Committee Member

Lorne Bonkowski


Pain is one of the cardinal signs of inflammation, but its production during the inflammatory process has been poorly delineated. While analgesic and antiedema activities have been well studied in the literature, neurogram studies of nerves directly involved with local inflammation have not been reported to date.

One purpose of this investigation was to determine if differences in neurogram patterns were apparent using different phlogistic agents and electrophysical recording of the inflammation-induced “pain.”