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Effect of selected adjuvants on metronidazole release from poly(ortho ester) matrix and computer optimization of the formulation
Date of Award
Dissertation - Pacific Access Restricted
Doctor of Philosophy (Ph.D.)
In the present study, a 8 x 4 mm biodegradable device was formulated using poly(ortho ester) and metronidazole for treatment of periodontitis. Investigation focussed upon determination of formulation parameters in the form of drug (metronidazole) and adjuvant concentrations (oleic acid and palmitic acid) and device thickness necessary to achieve constant release of 0.6 $\mu$g/hr over a period of 7 days and complete degradation of the device over a period of 11 to 13 days. Presence of oleic or palmitic acid influenced the release and erosion profile considerably. Thickness of the device did not have significant influence on the drug release. The DSC and NMR studies indicated absence of interaction between drug and polymer. Computer optimization studies indicate that the optimum formulation for 7 day constant drug delivery and disappearance in 13 days should contain 0.28% w/w of oleic acid and 5.26% w/w of metronidazole at the thickness of 400-450 or 500-550 $\mu$m. This is in close agreement with the optimum formulation which was obtained with the experimental data.
Junnarkar, Gunjan Harshad. (1995). Effect of selected adjuvants on metronidazole release from poly(ortho ester) matrix and computer optimization of the formulation. University of the Pacific, Dissertation - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2782
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