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Date of Award


Document Type

Dissertation - Pacific Access Restricted

Degree Name

Doctor of Philosophy (Ph.D.)


Pharmaceutics and Medicinal Chemistry

First Advisor

Ravindra C. Vasavada

First Committee Member

Patrick N. Catania

Second Committee Member

Madhukar G. Chaubal

Third Committee Member

Patrick R. Jones

Fourth Committee Member

Donald L. Sorby

Fifth Committee Member

Donald G. Floriddia

Sixth Committee Member

David S. Fries


In the present study, a 8 x 4 mm biodegradable device was formulated using poly(ortho ester) and metronidazole for treatment of periodontitis. Investigation focussed upon determination of formulation parameters in the form of drug (metronidazole) and adjuvant concentrations (oleic acid and palmitic acid) and device thickness necessary to achieve constant release of 0.6 μg/hr over a period of 7 days and complete degradation of the device over a period of 11 to 13 days. Presence of oleic or palmitic acid influenced the release and erosion profile considerably. Thickness of the device did not have significant influence on the drug release. The DSC and NMR studies indicated absence of interaction between drug and polymer. Computer optimization studies indicate that the optimum formulation for 7 day constant drug delivery and disappearance in 13 days should contain 0.28% w/w of oleic acid and 5.26% w/w of metronidazole at the thickness of 400-450 or 500-550 μm. This is in close agreement with the optimum formulation which was obtained with the experimental data.



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