Campus Access Only

All rights reserved. This publication is intended for use solely by faculty, students, and staff of University of the Pacific. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, now known or later developed, including but not limited to photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author or the publisher.

Date of Award

1995

Document Type

Dissertation - Pacific Access Restricted

Degree Name

Doctor of Philosophy (Ph.D.)

Department

Pharmaceutics and Medicinal Chemistry

First Advisor

Ravindra C. Vasavada

First Committee Member

Patrick N. Catania

Second Committee Member

Madhukar G. Chaubal

Third Committee Member

Patrick R. Jones

Fourth Committee Member

Donald L. Sorby

Fifth Committee Member

Donald G. Floriddia

Sixth Committee Member

David S. Fries

Abstract

In the present study, a 8 x 4 mm biodegradable device was formulated using poly(ortho ester) and metronidazole for treatment of periodontitis. Investigation focussed upon determination of formulation parameters in the form of drug (metronidazole) and adjuvant concentrations (oleic acid and palmitic acid) and device thickness necessary to achieve constant release of 0.6 μg/hr over a period of 7 days and complete degradation of the device over a period of 11 to 13 days. Presence of oleic or palmitic acid influenced the release and erosion profile considerably. Thickness of the device did not have significant influence on the drug release. The DSC and NMR studies indicated absence of interaction between drug and polymer. Computer optimization studies indicate that the optimum formulation for 7 day constant drug delivery and disappearance in 13 days should contain 0.28% w/w of oleic acid and 5.26% w/w of metronidazole at the thickness of 400-450 or 500-550 μm. This is in close agreement with the optimum formulation which was obtained with the experimental data.

Pages

139

To access this thesis/dissertation you must have a valid pacific.edu email address and log-in to Scholarly Commons.

Find in PacificSearch Find in ProQuest

Share

COinS

If you are the author and would like to grant permission to make your work openly accessible, please email