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Date of Award
1992
Document Type
Thesis - Pacific Access Restricted
Degree Name
Master of Science (M.S.)
Department
Physiology and Pharmacology
First Advisor
James Blankenship
First Committee Member
Marvin H. Malone
Second Committee Member
Denis J. Meerdink
Abstract
Putrescine, spermidine and spermine are classified as polyamines and are found in virtually all living tissues. Although polyamines have been proposed to influence cell proliferation and differentiation, the mechanism by which they do so is not well understood. Previous studies in our laboratory have been focused on the interconversion of spermidine and N8-acetylspermidine (N8-AcSpd) and the enzyme N8-AcSpd deacetylase. In the present study, a N8-AcSpd deacetylase inhibitor, 7-[N-(3-aminopropyl) amino] heptan-2-one (APAH) was employed to study the effect of N8-AcSpd deacetylase inhibition on proliferation of cultured cells.
This study for the first time shows the pharmacological effects of elevated N8-AcSpd levels and inhibition of N8-AcSpd deacetylation. Based on the fact that inhibition of N8-AcSpd deacetylation stimulates the growth of cells in culture, we propose to search for a new class of antitumor agents among the inhibitors of spermidine N8-acetyltransferase.
Pages
113
Recommended Citation
Wang, Zaijie. (1992). Effect of N⁸-acetylspermidine deacetylase inhibition on the growth of L1210 cells. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/2241
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