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Date of Award
Master of Science (M.S.)
James C. King
First Committee Member
Patrick N. Catania
Second Committee Member
W. J. Schneider
Third Committee Member
M. G. Chaubal
The basic unmedicated formula consists of dextran, sorbitol, Miranol 2 MCA Modified, and water. The major advantages of the film are 1) fast release rates, 2) ease of application to denuded skin without aggravation, and 3) lack of necessity for removal, hence no aggravation. However, it is extremely sensitive to moisture and elevated temperatures which is a major disadvantage. Excessive humidity will solubilize the film or make it too tacky to handle while very low humidity causes the film to lose its flexibility. Also, elevated temperatures remove moisture from the film and cause it to lose flexibility much as with low humidities.
This study was designed to evaluate further this new dosage form with respect to: (1) Modification of formula to minimize moisture sensitivity.; (2) Determination of a suitable packaging material.; (3) Determination of proper storage conditions.; (4) Determination of shelf-life of silver sulfadiazine and nitrofurazone dry foams.; (5) Determination of a suitable sterilization method(s).
Gostanian, Armen. (1975). Stability, packaging, storage, and sterilization of a medicated dry foam. University of the Pacific, Thesis. https://scholarlycommons.pacific.edu/uop_etds/1885
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