Title

Significance, Synthesis, and Characterization of HDAC Inhibitors

Poster Number

18A

Lead Author Major

Biochemistry

Lead Author Status

Senior

Second Author Major

Biological Sciences

Second Author Status

Sophomore

Third Author Major

Biological Sciences

Third Author Status

Sophomore

Fourth Author Major

Chemistry

Fourth Author Status

Freshman

Format

Poster Presentation (Research Day, April 30)

Faculty Mentor Name

Qinliang Zhao

Faculty Mentor Department

Chemistry

Abstract/Artist Statement

Constant development for new medications and therapies is required due to the advancement of tumors and fast-growing resistance to existing anticancer drugs. Histone deacetylase (HDAC), overexpressed in a variety of cancer cells, condenses the chromatin structure of tumor suppressor genes, cell-cycle inhibitor genes, and apoptosis inducer genes. Our innovative approach to these problems is to develop bifunctional platinum (Pt) complexes stabilized by HDAC inhibitors. Each inhibitor comprises of a main scaffold, a zinc-binding group, a protein recognition cap and also a coordination site to metal ions. Several HDAC inhibitors were synthesized through multiple-step synthesis, purified, and characterized by X-ray crystallography, MS, and NMR analysis. The dual function of the Pt complexes will be realized while the DNAs in the cancer cells are relaxed by the HDAC inhibitors and could easily be attached by the Pt cores.

Location

Information Commons, William Knox Holt Memorial Library and Learning Center

Start Date

30-4-2022 1:00 PM

End Date

30-4-2022 3:00 PM

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Apr 30th, 1:00 PM Apr 30th, 3:00 PM

Significance, Synthesis, and Characterization of HDAC Inhibitors

Information Commons, William Knox Holt Memorial Library and Learning Center

Constant development for new medications and therapies is required due to the advancement of tumors and fast-growing resistance to existing anticancer drugs. Histone deacetylase (HDAC), overexpressed in a variety of cancer cells, condenses the chromatin structure of tumor suppressor genes, cell-cycle inhibitor genes, and apoptosis inducer genes. Our innovative approach to these problems is to develop bifunctional platinum (Pt) complexes stabilized by HDAC inhibitors. Each inhibitor comprises of a main scaffold, a zinc-binding group, a protein recognition cap and also a coordination site to metal ions. Several HDAC inhibitors were synthesized through multiple-step synthesis, purified, and characterized by X-ray crystallography, MS, and NMR analysis. The dual function of the Pt complexes will be realized while the DNAs in the cancer cells are relaxed by the HDAC inhibitors and could easily be attached by the Pt cores.