Significance, Synthesis, and Characterization of HDAC Inhibitors
Poster Number
18A
Format
Poster Presentation (Research Day, April 30)
Faculty Mentor Name
Qinliang Zhao
Faculty Mentor Department
Chemistry
Abstract/Artist Statement
Constant development for new medications and therapies is required due to the advancement of tumors and fast-growing resistance to existing anticancer drugs. Histone deacetylase (HDAC), overexpressed in a variety of cancer cells, condenses the chromatin structure of tumor suppressor genes, cell-cycle inhibitor genes, and apoptosis inducer genes. Our innovative approach to these problems is to develop bifunctional platinum (Pt) complexes stabilized by HDAC inhibitors. Each inhibitor comprises of a main scaffold, a zinc-binding group, a protein recognition cap and also a coordination site to metal ions. Several HDAC inhibitors were synthesized through multiple-step synthesis, purified, and characterized by X-ray crystallography, MS, and NMR analysis. The dual function of the Pt complexes will be realized while the DNAs in the cancer cells are relaxed by the HDAC inhibitors and could easily be attached by the Pt cores.
Location
Information Commons, William Knox Holt Memorial Library and Learning Center
Start Date
30-4-2022 1:00 PM
End Date
30-4-2022 3:00 PM
Significance, Synthesis, and Characterization of HDAC Inhibitors
Information Commons, William Knox Holt Memorial Library and Learning Center
Constant development for new medications and therapies is required due to the advancement of tumors and fast-growing resistance to existing anticancer drugs. Histone deacetylase (HDAC), overexpressed in a variety of cancer cells, condenses the chromatin structure of tumor suppressor genes, cell-cycle inhibitor genes, and apoptosis inducer genes. Our innovative approach to these problems is to develop bifunctional platinum (Pt) complexes stabilized by HDAC inhibitors. Each inhibitor comprises of a main scaffold, a zinc-binding group, a protein recognition cap and also a coordination site to metal ions. Several HDAC inhibitors were synthesized through multiple-step synthesis, purified, and characterized by X-ray crystallography, MS, and NMR analysis. The dual function of the Pt complexes will be realized while the DNAs in the cancer cells are relaxed by the HDAC inhibitors and could easily be attached by the Pt cores.