Title

Comparison of Cisplatin and Nitrogen Mustard Derivatives in Cancer Treatment

Lead Author Major

Biochemistry

Lead Author Status

Senior

Second Author Major

Biochemistry

Second Author Status

Senior

Format

Oral Presentation

Faculty Mentor Name

Qinliang Zhao

Faculty Mentor Department

Chemistry

Abstract/Artist Statement

Platinum-containing complexes and nitrogen mustard derivatives are two drug families for cancer treatment. The two core drugs of the families were Cisplatin, created in 1845, and Chlormethine (mustine), created in 1925. Cisplatin is used to treat cancers like ovarian, breast, lung, esophageal, and many more. Nitrogen mustards are used as palliative care in lung and breast cancers as well as treatment for Hodgkin’s disease. The two families of drugs in treating cancer will be compared in terms of mechanism, side effects, and resistance factors. The report will also focus on the importance of the Pt metal in cancer treatment.

Location

University of the Pacific, 3601 Pacific Ave., Stockton, CA 95211

Start Date

24-4-2021 4:00 PM

End Date

24-4-2021 4:15 PM

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Apr 24th, 4:00 PM Apr 24th, 4:15 PM

Comparison of Cisplatin and Nitrogen Mustard Derivatives in Cancer Treatment

University of the Pacific, 3601 Pacific Ave., Stockton, CA 95211

Platinum-containing complexes and nitrogen mustard derivatives are two drug families for cancer treatment. The two core drugs of the families were Cisplatin, created in 1845, and Chlormethine (mustine), created in 1925. Cisplatin is used to treat cancers like ovarian, breast, lung, esophageal, and many more. Nitrogen mustards are used as palliative care in lung and breast cancers as well as treatment for Hodgkin’s disease. The two families of drugs in treating cancer will be compared in terms of mechanism, side effects, and resistance factors. The report will also focus on the importance of the Pt metal in cancer treatment.