Title

In Vitro Activity of Nucleoside Analogs on the Veterinary Protozoan Parasite Tritrichomonas Foetus

Poster Number

41

Lead Author Major

Biological Sciences

Format

Poster Presentation

Faculty Mentor Name

Kirkwood Land

Faculty Mentor Department

Biological Sciences

Abstract/Artist Statement

We carried out a structure activity analysis in Tritrichomonas foetus of a series of adenosine and 7-deazaadenosine analogues. The most potent compounds were found to be the arabino derivatives some of which are potent inhibitors of S-adenosylhomocysteine hydrolase of the human parasite Trichomonas vaginalis. The 9- [2-deoxy-2-azido-β,D-arabinofuranosyl)adenine was found to completely inhibit T. foetus at 10 AμM concentrations with IC50 5 AμM. Of the purine modified antibiotics tested, toyocamycin and formycin completely inhibited T. foetus growth at 100 AμM concentrations with IC50 9.3 AμM and 10.3 AμM, respectively. These analogues may serve as new lead compounds for drug discovery against T. foetus.

Location

DeRosa University Center, Ballroom

Start Date

20-4-2013 1:00 PM

End Date

20-4-2013 3:00 PM

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Apr 20th, 1:00 PM Apr 20th, 3:00 PM

In Vitro Activity of Nucleoside Analogs on the Veterinary Protozoan Parasite Tritrichomonas Foetus

DeRosa University Center, Ballroom

We carried out a structure activity analysis in Tritrichomonas foetus of a series of adenosine and 7-deazaadenosine analogues. The most potent compounds were found to be the arabino derivatives some of which are potent inhibitors of S-adenosylhomocysteine hydrolase of the human parasite Trichomonas vaginalis. The 9- [2-deoxy-2-azido-β,D-arabinofuranosyl)adenine was found to completely inhibit T. foetus at 10 AμM concentrations with IC50 5 AμM. Of the purine modified antibiotics tested, toyocamycin and formycin completely inhibited T. foetus growth at 100 AμM concentrations with IC50 9.3 AμM and 10.3 AμM, respectively. These analogues may serve as new lead compounds for drug discovery against T. foetus.