Title

In Vitro Activity of Calpain Inhibitors Against Tritrichomonas foetus

Poster Number

56

Lead Author Major

Biological Sciences

Format

Poster Presentation

Faculty Mentor Name

Kirkwood Land

Faculty Mentor Department

Biological Sciences

Abstract/Artist Statement

Calpains have been shown to have a pathogenic role in many microbial diseases. In this study, we have examined the role of calpain in the in vitro viability of the veterinary protozoal parasite Tritrichomonas foetus. Several calpain inhibitors were tested on the in vitro growth of T. foetus strain D1, the most virulent strain characterized in the laboratory. Although not as potent against T. foetus as other trichomonads, the 50% reduction in viability suggests a important role of these enzymes in viability. This finding warrants further study on role of calpains in the life cycle of this important pathogen.

Location

Grave Covell

Start Date

21-4-2012 10:00 AM

End Date

21-4-2012 12:00 PM

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Apr 21st, 10:00 AM Apr 21st, 12:00 PM

In Vitro Activity of Calpain Inhibitors Against Tritrichomonas foetus

Grave Covell

Calpains have been shown to have a pathogenic role in many microbial diseases. In this study, we have examined the role of calpain in the in vitro viability of the veterinary protozoal parasite Tritrichomonas foetus. Several calpain inhibitors were tested on the in vitro growth of T. foetus strain D1, the most virulent strain characterized in the laboratory. Although not as potent against T. foetus as other trichomonads, the 50% reduction in viability suggests a important role of these enzymes in viability. This finding warrants further study on role of calpains in the life cycle of this important pathogen.