Title

Analysis of new Theosemicarbazones Against the Human Protozoal Parasite Trichomonas vaginalis

Poster Number

52

Lead Author Major

Biological Sciences

Format

Poster Presentation

Faculty Mentor Name

Kirkwood Land

Faculty Mentor Department

Biological Sciences

Abstract/Artist Statement

Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The current FDA approved drugs for treatment of human trichomoniasis are metronidazole and tinidazole. Current data from the US Centers for Disease Control and Prevention have suggested that almost 5% of all clinical cases of trichomoniasis show some level of resistance to these drugs. In search of new chemotherapies, we have screened a small compound library of thiosemicarbazones. Our laboratory has previously shown that this group of cysteine protease inhibitors has potent inhibitory activity against trichomonads protozoa. Our goal is to identify potential new chemotherapies against this important human parasite.

Location

Grave Covell

Start Date

21-4-2012 10:00 AM

End Date

21-4-2012 12:00 PM

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Apr 21st, 10:00 AM Apr 21st, 12:00 PM

Analysis of new Theosemicarbazones Against the Human Protozoal Parasite Trichomonas vaginalis

Grave Covell

Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The current FDA approved drugs for treatment of human trichomoniasis are metronidazole and tinidazole. Current data from the US Centers for Disease Control and Prevention have suggested that almost 5% of all clinical cases of trichomoniasis show some level of resistance to these drugs. In search of new chemotherapies, we have screened a small compound library of thiosemicarbazones. Our laboratory has previously shown that this group of cysteine protease inhibitors has potent inhibitory activity against trichomonads protozoa. Our goal is to identify potential new chemotherapies against this important human parasite.