Effects of Serine Protease Inhibitors on the Human Protozoal Parasite Trichomonas vaginalis
Poster Number
45
Format
Poster Presentation
Faculty Mentor Name
Kirkwood Land
Faculty Mentor Department
Biological Sciences
Abstract/Artist Statement
Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The mechanism of pathogenesis is thought to involve proteases. In this study, we have focused on the possible role of serine proteases in the pathogenesis of this parasite. In related protozoal parasites, like malaria and trypanosomes, serine proteases play a key role in processing virulence factors in the endomembrane system. To begin to understand the possible role of these enzymes, we have screened a number of different commercial serine protease inhibitors on the growth of the parasite in culture. The effects of this inhibitors should shed light on the potential role of these enzymes in the life cycle of this important human parasite.
Location
Grave Covell
Start Date
21-4-2012 10:00 AM
End Date
21-4-2012 12:00 PM
Effects of Serine Protease Inhibitors on the Human Protozoal Parasite Trichomonas vaginalis
Grave Covell
Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The mechanism of pathogenesis is thought to involve proteases. In this study, we have focused on the possible role of serine proteases in the pathogenesis of this parasite. In related protozoal parasites, like malaria and trypanosomes, serine proteases play a key role in processing virulence factors in the endomembrane system. To begin to understand the possible role of these enzymes, we have screened a number of different commercial serine protease inhibitors on the growth of the parasite in culture. The effects of this inhibitors should shed light on the potential role of these enzymes in the life cycle of this important human parasite.