Title

Effects of Serine Protease Inhibitors on the Human Protozoal Parasite Trichomonas vaginalis

Poster Number

45

Lead Author Major

Biological Sciences

Format

Poster Presentation

Faculty Mentor Name

Kirkwood Land

Faculty Mentor Department

Biological Sciences

Abstract/Artist Statement

Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The mechanism of pathogenesis is thought to involve proteases. In this study, we have focused on the possible role of serine proteases in the pathogenesis of this parasite. In related protozoal parasites, like malaria and trypanosomes, serine proteases play a key role in processing virulence factors in the endomembrane system. To begin to understand the possible role of these enzymes, we have screened a number of different commercial serine protease inhibitors on the growth of the parasite in culture. The effects of this inhibitors should shed light on the potential role of these enzymes in the life cycle of this important human parasite.

Location

Grave Covell

Start Date

21-4-2012 10:00 AM

End Date

21-4-2012 12:00 PM

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Apr 21st, 10:00 AM Apr 21st, 12:00 PM

Effects of Serine Protease Inhibitors on the Human Protozoal Parasite Trichomonas vaginalis

Grave Covell

Trichomonas vaginalis is a protozoal parasite that causes trichomoniasis in humans. The mechanism of pathogenesis is thought to involve proteases. In this study, we have focused on the possible role of serine proteases in the pathogenesis of this parasite. In related protozoal parasites, like malaria and trypanosomes, serine proteases play a key role in processing virulence factors in the endomembrane system. To begin to understand the possible role of these enzymes, we have screened a number of different commercial serine protease inhibitors on the growth of the parasite in culture. The effects of this inhibitors should shed light on the potential role of these enzymes in the life cycle of this important human parasite.