Title

3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro

Poster Number

29

Format

Poster Presentation

Abstract/Artist Statement

Trichomonas vaginalis is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Today, trichomoniasis is one of the most common sexually- transmitted diseases. The current FDA approved treatment is metronidazole. However, there are strains that display resistance to metronidazole, pressing the need for alternative chemotherapies to be found. To support this effort, a compound library of 3,4-dichloroaniline amides were screened in vitro against the T1 and G3 strains of the organism. Of the twenty-one compounds, six were effective at inhibited growth on the G3 strain and seven were effective on the T1 strain.

Location

DeRosa University Center, Ballroom B

Start Date

2-5-2009 1:00 PM

End Date

2-5-2009 3:00 PM

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3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro

DeRosa University Center, Ballroom B

Trichomonas vaginalis is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Today, trichomoniasis is one of the most common sexually- transmitted diseases. The current FDA approved treatment is metronidazole. However, there are strains that display resistance to metronidazole, pressing the need for alternative chemotherapies to be found. To support this effort, a compound library of 3,4-dichloroaniline amides were screened in vitro against the T1 and G3 strains of the organism. Of the twenty-one compounds, six were effective at inhibited growth on the G3 strain and seven were effective on the T1 strain.