Title

3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro

Poster Number

2

Format

Poster Presentation

Faculty Mentor Name

Kirkwood Land

Abstract/Artist Statement

Trichomonas vagina/is is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Currently, trichomoniasis is one of the most common sexually-transmitted diseases. The current FDA approved treatment is metronidazole. Due to the emergence of clinical drug resistant strains, there is a need to identify alternative chemotherapies. To support this effort, we have screened in vitro a compound library of3,4-dichloroaniline amides. Of the twelve compounds, five were effective at inhibiting parasite growth. IC50 values are currently being determined for these five compounds, as well as structure-activity relationships.

Location

Wendell Phillips Center, 1st floor hallways

Start Date

3-5-2008 1:00 PM

End Date

3-5-2008 3:00 PM

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May 3rd, 1:00 PM May 3rd, 3:00 PM

3,4-Dichloroaniline Amides as Anti-trichomonal Agents: Structure Activity Analysis of a Compound Library in vitro

Wendell Phillips Center, 1st floor hallways

Trichomonas vagina/is is a protozoan that causes the sexually-transmitted disease trichomoniasis in humans. The organism infects both men and women; however, men are asymptomatic, making treatment difficult between partners. Currently, trichomoniasis is one of the most common sexually-transmitted diseases. The current FDA approved treatment is metronidazole. Due to the emergence of clinical drug resistant strains, there is a need to identify alternative chemotherapies. To support this effort, we have screened in vitro a compound library of3,4-dichloroaniline amides. Of the twelve compounds, five were effective at inhibiting parasite growth. IC50 values are currently being determined for these five compounds, as well as structure-activity relationships.