Title

Anion exchange of chloride ions in Re2(CH3COO)2Cl4·2H2O and [Re2(CH3COO)2(9-ETAH)2]Cl4

Poster Number

1

Format

Poster Presentation

Abstract/Artist Statement

Rhenium metal complexes show anticancer activity which has been proposed to be the result of binding to purine nucleobases in DNA. This study uses 9-ethyladenine to simulate adenine in a natural system in which position nine is attached to the sugar-phosphate backbone of DNA. Reaction of Re2(O2CCH3)2Cl4·2H2O, a quadruply bonded compound, with 9-ethyladenine results in the isolation of the product [Re2(OAc)2(9-EtAH)2]Cl4. The focus of this research study is to isolate this product with a variety of anions. Anion exchange of the chloride ions in either the reactant or the product dimetal compounds will give us spectroscopic information and may enable us to isolate crystalline products. Infrared spectroscopy, mass spectrometry, and 1H NMR spectroscopy will be used to characterize the products. The results of the different exchange reactions will be discussed.

Location

Pacific Geosciences Center

Start Date

24-4-2004 9:00 AM

End Date

24-4-2004 5:00 PM

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Apr 24th, 9:00 AM Apr 24th, 5:00 PM

Anion exchange of chloride ions in Re2(CH3COO)2Cl4·2H2O and [Re2(CH3COO)2(9-ETAH)2]Cl4

Pacific Geosciences Center

Rhenium metal complexes show anticancer activity which has been proposed to be the result of binding to purine nucleobases in DNA. This study uses 9-ethyladenine to simulate adenine in a natural system in which position nine is attached to the sugar-phosphate backbone of DNA. Reaction of Re2(O2CCH3)2Cl4·2H2O, a quadruply bonded compound, with 9-ethyladenine results in the isolation of the product [Re2(OAc)2(9-EtAH)2]Cl4. The focus of this research study is to isolate this product with a variety of anions. Anion exchange of the chloride ions in either the reactant or the product dimetal compounds will give us spectroscopic information and may enable us to isolate crystalline products. Infrared spectroscopy, mass spectrometry, and 1H NMR spectroscopy will be used to characterize the products. The results of the different exchange reactions will be discussed.