Title

Total synthesis of new inhibitors for carbohydrate processing enzymes

Poster Number

14

Format

Poster Presentation

Abstract/Artist Statement

C-Glycosides are the chemically and metabolically stable analogs of carbohydrates. They can compete with natural carbohydrates in many biochemical processes. In particular, C-glycosides may interact with enzymes (the biocatalysts that transform carbohydrates) and deactivate (inhibit) them. Therefore, C-glycosides are potential therapeutic agents against many diseases. We synthesized new potential inhibitors for these enzymes, which formulas are shown below. The series of these compounds will be expanded and tested for the enzyme inhibitory activity.

Location

Pacific Geosciences Center

Start Date

24-4-2004 9:00 AM

End Date

24-4-2004 5:00 PM

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Apr 24th, 9:00 AM Apr 24th, 5:00 PM

Total synthesis of new inhibitors for carbohydrate processing enzymes

Pacific Geosciences Center

C-Glycosides are the chemically and metabolically stable analogs of carbohydrates. They can compete with natural carbohydrates in many biochemical processes. In particular, C-glycosides may interact with enzymes (the biocatalysts that transform carbohydrates) and deactivate (inhibit) them. Therefore, C-glycosides are potential therapeutic agents against many diseases. We synthesized new potential inhibitors for these enzymes, which formulas are shown below. The series of these compounds will be expanded and tested for the enzyme inhibitory activity.