Title

Reactivity of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 9-ethyladenine and 1,4,7-triazacyclonane.

Poster Number

19

Format

Poster Presentation

Abstract/Artist Statement

Dinuclear metal carboxylate compounds have been shown to repress tumor growth. It is proposed that the anticancer activity of dinuclear metal systems is a result of their interaction with the purine DNA nucleobases, adenine and guanine. Two possible coordination modes for these ligands are bridging the dinuclear core or chelating to one metal center of the dinuclear core. This study focuses on the chelating coordination mode. Reactions of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 1,4,7-triazacyclonane (TACN) and 9-ethyladenine (9-EtAH) may result in isolation of products containing a chelating nucleobase. The coordinated solvent molecules of [Mo2(02CCH3)2(CH3CN)6][BF4]2 will be replaced by the strongly coordinating tridentate TACN macrocycle and the added 9-EtAH will be forced to chelate to the remaining equatorial metal sites. The reactions of Re2(02CCH3)4Cl2 with TACN and 9-EtAH will also be explored. Preliminary results of newly synthesized compounds will be discussed.

Location

Pacific Geosciences Center

Start Date

20-4-2002 9:00 AM

End Date

20-4-2002 5:00 PM

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Apr 20th, 9:00 AM Apr 20th, 5:00 PM

Reactivity of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 9-ethyladenine and 1,4,7-triazacyclonane.

Pacific Geosciences Center

Dinuclear metal carboxylate compounds have been shown to repress tumor growth. It is proposed that the anticancer activity of dinuclear metal systems is a result of their interaction with the purine DNA nucleobases, adenine and guanine. Two possible coordination modes for these ligands are bridging the dinuclear core or chelating to one metal center of the dinuclear core. This study focuses on the chelating coordination mode. Reactions of dimolybdenum(II) and dirhenium(III) carboxylate compounds with 1,4,7-triazacyclonane (TACN) and 9-ethyladenine (9-EtAH) may result in isolation of products containing a chelating nucleobase. The coordinated solvent molecules of [Mo2(02CCH3)2(CH3CN)6][BF4]2 will be replaced by the strongly coordinating tridentate TACN macrocycle and the added 9-EtAH will be forced to chelate to the remaining equatorial metal sites. The reactions of Re2(02CCH3)4Cl2 with TACN and 9-EtAH will also be explored. Preliminary results of newly synthesized compounds will be discussed.