Title

Lipid-Coated, pH-Sensitive Magnesium Phosphate Particles for Intracellular Protein Delivery

Document Type

Article

Publication Title

Pharmaceutical Research

ISSN

1573-904X

Volume

36

Issue

6

DOI

10.1007/s11095-019-2607-6

First Page

81

Last Page

81

Publication Date

4-11-2019

Abstract

PURPOSE: To develop cationic lipid-coated magnesium phosphate nanoparticles (LPP) for intracellular catalase (CAT) delivery.

METHODS: Magnesium phosphate nanoparticles (MgP NP) were prepared by micro-emulsion precipitation and mixed with catalase-loaded cationic liposomes (DOTAP/cholesterol) to yield LPP formulation of catalase (LPP-CAT). The size and ζ-potential of LPP-CAT were measured by dynamic light scattering. The pH-sensitivity of LPP-CAT was determined by monitoring their degradation of hydrogen peroxide (H

RESULTS: LPP-CAT were successfully prepared and carried an average diameter ofζ -potential of about +40 mV. At pH 5.5, LPP-CAT degraded H

CONCLUSION: LPP represents a promising nano-system for intracellular protein delivery.

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