Date of Award
Master of Physician Assistant Studies
Physician Assistant Education
Purpose: To compare the efficacy of intra-articular (IA) injections of hyaluronic acid (HA) viscosupplementation to platelet-rich plasma (PRP) for degenerative osteoarthritis (OA) knee pain and function
Methods: A review of current high-level evidence research articles on the subject matter
Results: PRP is more effective than HA injections for mild knee OA, but there are no significant differences between PRP and HA in effectiveness for more advanced knee OA. Combination therapy of HA and PRP is superior to PRP or HA alone. Multiple PRP injections also improve pain and function in comparison to multiple HA injections or single PRP injections.
Conclusion: The existing clinical studies show promising data that PRP is a more effective treatment for early knee OA in comparison to HA, but further studies need to be performed for more conclusive results.
Wong, Dawn G., "Comparing Intra-Articular Injections of Hyaluronic Acid versus Platelet Rich Plasma for Osteoarthritis Knee Pain" (2019). Physician's Assistant Program Capstones. 44.