Opposing gradients pattern the neural tube. TGFbs (blue) from the epidermis and Sonic Hedgehog (Shh, red) from the notochord pattern the dorsal/ventral axis of the neural tube. Neurons exposed to a high concentration of TGFbs will become sensory neurons, those exposed to high levels of Shh will become motor neurons. Neurons exposed to low levels of both will become interneurons. Figure by Amanda Lo and Ajna Rivera
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patterning, specification, nervous system, neural tube, notochord, TGFb, Shh, neurons