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opposing gradient.svg (18 kB)
Creation Date
2019
Description
Opposing gradients pattern the neural tube. TGFbs (blue) from the epidermis and Sonic Hedgehog (Shh, red) from the notochord pattern the dorsal/ventral axis of the neural tube. Neurons exposed to a high concentration of TGFbs will become sensory neurons, those exposed to high levels of Shh will become motor neurons. Neurons exposed to low levels of both will become interneurons. Figure by Amanda Lo and Ajna Rivera
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 International License.
Keywords
patterning, specification, nervous system, neural tube, notochord, TGFb, Shh, neurons
