Event Title
The Never-Ending Story of the Aryl Hydrocarbon Receptor
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Location
Biology Building, Room 101
Start Date
22-2-2018 6:00 PM
End Date
22-2-2018 7:00 PM
Description
The aryl hydrocarbon receptor is a ligand-activated signaling molecule with diverse biological functions ranging from regulation of enzymes for drug metabolism to modulation of immune response. It also plays a role in cell growth which may affect many types of cancer. My laboratory has been studying the human aryl hydrocarbon receptor for two decades now at Pacific and our study primarily focuses on how this protein interacts with other proteins and DNA. Essentially we are trying to understand how this receptor works at the molecular level with the hope of designing drugs rationally to modulate the function of this protein for disease treatment. This seminar will provide some highlights and our findings of this receptor.
The Never-Ending Story of the Aryl Hydrocarbon Receptor
Biology Building, Room 101
The aryl hydrocarbon receptor is a ligand-activated signaling molecule with diverse biological functions ranging from regulation of enzymes for drug metabolism to modulation of immune response. It also plays a role in cell growth which may affect many types of cancer. My laboratory has been studying the human aryl hydrocarbon receptor for two decades now at Pacific and our study primarily focuses on how this protein interacts with other proteins and DNA. Essentially we are trying to understand how this receptor works at the molecular level with the hope of designing drugs rationally to modulate the function of this protein for disease treatment. This seminar will provide some highlights and our findings of this receptor.
Speaker Bio
Pro fessor Chan received his Doctor of Pharmacy degree from UCSF and continued on with his study at UCSF to obtain a Ph.D. degree in Pharmaceutical Chemistry, studying the active site structure of cytochrome P4504A1, a drug metabolizing enzyme. He then went on to study another drug metabolizing enzyme – epoxide hydrolase – at UC Davis as a postdoctoral researcher for a year, followed by a four - year postdoc at Northwestern University Medical School, where he began his study of the aryl hydrocarbon receptor. In 1 996, he became an assistant professor at the Pacific Pharmacy School. He has been studying the aryl hydrocarbon receptor ever since with the support from the National Institutes of Health.