OGT and OGA mRNA expression in Squamous Oral Cell Carcinoma: public data set analysis.

Pedro Morales Li, University of the Paacific
Desmond Ng, University of the Pacific
Ana Carolina Morandini, University of the Pacific
Erivan Ramos-Junior, University of the Pacific

Introduction/Context/Diagnosis

Hyperglycemia is a condition in which an excessive amount of glucose is present in the blood. Recent studies suggest that there is a higher cancer incidence in people with type 2 diabetes (DM2). The abundance of glucose increases the intracellular flux through glycolysis, pentose phosphate pathway and hexosamine biosynthetic pathway (HBP). High glucose (HG) triggers several direct and indirect mechanisms that promote cancer progression, such as epithelial mesenchymal transition (EMT). The abundance of glucose increases the flux through glycolysis, pentose phosphate pathway and hexosamine biosynthetic pathway (HBP). The final product of HBP is the UDP-N-acetyl-D-glucosamine (UDP-GlcNAc). One of the enzymes used to manufacture UDP-GlcNAc is glutamine-fructose-6-phosphate amidotransferase (GFAT), of which increased expression has been shown to confer worse prognoses in some cancers (e.g. pancreatic, prostate, colorectal tumors) and better prognoses in others (e.g. gastric tumors). UDP-GlcNAc is used as substrate for the post translational modification (PTM) O-GlcNacylation of nucleocytoplasmatic and mitochondrial proteins. The O-GlcNAcylation is catalyzed by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to serine/threonine residues using UDP-GlcNAc as substrate donor. The removal of this monosaccharide is catalyzed by the enzyme O-GlcNAcase (OGA), also referred to as meningioma expressed antigen 5 (MGEA5). Here we investigated the expression of OGT and OGA in Oral squamous cell carcinoma (OSCC) using a public data bank in Genome Expression Omnibus (GEO).

 

OGT and OGA mRNA expression in Squamous Oral Cell Carcinoma: public data set analysis.

Hyperglycemia is a condition in which an excessive amount of glucose is present in the blood. Recent studies suggest that there is a higher cancer incidence in people with type 2 diabetes (DM2). The abundance of glucose increases the intracellular flux through glycolysis, pentose phosphate pathway and hexosamine biosynthetic pathway (HBP). High glucose (HG) triggers several direct and indirect mechanisms that promote cancer progression, such as epithelial mesenchymal transition (EMT). The abundance of glucose increases the flux through glycolysis, pentose phosphate pathway and hexosamine biosynthetic pathway (HBP). The final product of HBP is the UDP-N-acetyl-D-glucosamine (UDP-GlcNAc). One of the enzymes used to manufacture UDP-GlcNAc is glutamine-fructose-6-phosphate amidotransferase (GFAT), of which increased expression has been shown to confer worse prognoses in some cancers (e.g. pancreatic, prostate, colorectal tumors) and better prognoses in others (e.g. gastric tumors). UDP-GlcNAc is used as substrate for the post translational modification (PTM) O-GlcNacylation of nucleocytoplasmatic and mitochondrial proteins. The O-GlcNAcylation is catalyzed by O-GlcNAc transferase (OGT), which attaches O-GlcNAc to serine/threonine residues using UDP-GlcNAc as substrate donor. The removal of this monosaccharide is catalyzed by the enzyme O-GlcNAcase (OGA), also referred to as meningioma expressed antigen 5 (MGEA5). Here we investigated the expression of OGT and OGA in Oral squamous cell carcinoma (OSCC) using a public data bank in Genome Expression Omnibus (GEO).