Differential expression of adenosine receptors and ectonucleotidases in healthy and periodontitis samples: a Gene Expression Omnibus (GEO) analysis

Alyssa Kim, University of the Pacific Arthur A. Dugoni School of Dentistry
Greg Polonsky, University of the Pacific Arthur A. Dugoni School of Dentistry
Erivan S. Ramos-Junior, University of the Pacific Arthur A. Dugoni School of Dentistry
Ana Carolina Morandini, University of the Pacific Arthur A. Dugoni School of Dentistry

This work was supported by Research Enhancement Award to ACM [Award 03-Activity 117] from the Arthur Dugoni School of Dentistry

Introduction/Context/Diagnosis

OBJECTIVES: Adenosine Triphosphate (ATP) is an organic molecule that stores energy and drives the processes in living organisms. Despite its importance in terms of biochemical processes, ATP outside of cell is a “danger signal” that indicates inflammation. ATP concentration in the extracellular environment is tightly regulated by ectonucleotidases such as CD39 and CD73, being hydrolysed into adenosine nucleoside. Adenosine signal through adenosine receptors (ADORA1, 2A, 2B and 3). Here, we analysed the expression of the subset of ectonucleotidases and adenosine receptors in periodontitis and healthy samples.

 

Differential expression of adenosine receptors and ectonucleotidases in healthy and periodontitis samples: a Gene Expression Omnibus (GEO) analysis

OBJECTIVES: Adenosine Triphosphate (ATP) is an organic molecule that stores energy and drives the processes in living organisms. Despite its importance in terms of biochemical processes, ATP outside of cell is a “danger signal” that indicates inflammation. ATP concentration in the extracellular environment is tightly regulated by ectonucleotidases such as CD39 and CD73, being hydrolysed into adenosine nucleoside. Adenosine signal through adenosine receptors (ADORA1, 2A, 2B and 3). Here, we analysed the expression of the subset of ectonucleotidases and adenosine receptors in periodontitis and healthy samples.