Inflammasomes and danger signals in the immune system
Contribution to Book
Reference Module in Biomedical Research
Michael J. Caplan
The innate immune system has evolved to recognize both pathogen- and damage-associated molecular patterns (PAMPs and DAMPs), which represent conserved microbial structures or generic markers of stress or damage, respectively, and to generate an appropriate response. One such response is the production of the critical cytokines interleukin-1β and interleukin-18, which follows incorporation of PAMP and DAMP signals, and requires the activation of protein complexes termed inflammasomes to generate mature cytokines.
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ATP; Caspase; DAMP; HMGB1; Immunology; Inflammasome; Inflammation; Interleukin-1β; NLRP3; Nod-like receptors; PAMP; Toll-like receptors
Lai, Hsin-Chih; Al-Kuhlani, Mufadhal; Ojcius, David M.; and Pettengill, Matthew A., "Inflammasomes and danger signals in the immune system" (2014). Dugoni School of Dentistry Faculty Books and Book Chapters. 8.