Title

Current status of liposomal porphyrinoid photosensitizers

ORCiD

Nejat Düzgüneş: 0000-0001-6159-1391

Document Type

Article

Publication Title

Drug Discovery Today

ISSN

1359-6446

Volume

18

Issue

15-16

DOI

10.1016/j.drudis.2013.04.003

First Page

776

Last Page

784

Publication Date

8-1-2013

Abstract

The complete eradication of various targets, such as infectious agents or cancer cells, while leaving healthy host cells untouched, is still a great challenge faced in the field of medicine. Photodynamic therapy (PDT) seems to be a promising approach for anticancer treatment, as well as to combat various dermatologic and ophthalmic diseases and microbial infections. The application of liposomes as delivery systems for porphyrinoids has helped overcome many drawbacks of conventional photosensitizers and facilitated the development of novel effective photosensitizers that can be encapsulated in liposomes. The development, preclinical studies and future directions for liposomal delivery of conventional and novel photosensitizers are reviewed. © 2013 Elsevier Ltd. All rights reserved.

Share

COinS