Title

Monosynaptic excitation of preganglionic vasomotor neurons by subretrofacial neurons of the rostral ventrolateral medulla.

ORCiD

Dr. Ove A. Peters: 0000-0001-5222-8718

Document Type

Article

Publication Title

Brain research

ISSN

0006-8993

Volume

634

Issue

2

First Page

227

Last Page

234

Publication Date

1-21-1994

Abstract

Extracellular single unit recordings were made from barosensitive neurons in the subretrofacial nucleus (SRF) of the rostral ventrolateral medulla in chloralose-anaesthetised cats. At the same time, single preganglionic neuron activity was recorded from filaments of the cervical sympathetic trunk (CST); barosensitive units were selected for study. Evidence for monosynaptic connections between the two neuron groups was sought by cross-correlation analysis of their ongoing activity. Cross-correlograms of 16/16 SRF/CST neuron pairs showed a broad peak (100-200ms wide), reflecting the synchronizing action of arterial baroreceptors on both neurons' activity. Two of the 16 cross-correlograms additionally showed a robust, statistically significant, narrow peak of a single 2 ms bin width, providing the first physiological demonstration that ventrolateral medullary neurons monosynaptically excite preganglionic sympathetic neurons. Deductions are made about the strength, convergence and divergence of the connection.

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