Design of biocompatible pH-sensitive liposomes for drug and gene delivery
239th American Chemical Society (ACS) National Meeting
American Chemical Society (ACS)
San Francisco, CA
March 21-25, 2010
Date of Presentation
Since the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails.
Samoshina, N. M.,
Franz, A. H.,
Szoka, F. C.,
Samoshin, V. V.
Design of biocompatible pH-sensitive liposomes for drug and gene delivery.
Paper presented at 239th American Chemical Society (ACS) National Meeting in San Francisco, CA.