Design of biocompatible pH-sensitive liposomes for drug and gene delivery

Authors

Xin Guo, University of the PacificFollow
Nataliya M. Samoshina, University of the PacificFollow
Haigang Chen
Babora Brazdova, University of the PacificFollow
Andreas H. Franz, University of the PacificFollow
Huizhen ZhangFollow
Francis C. Szoka
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Conference Presentation

Department

Chemistry

Conference Title

239th American Chemical Society (ACS) National Meeting

Organization

American Chemical Society (ACS)

Location

San Francisco, CA

Conference Dates

March 21-25, 2010

Date of Presentation

3-24-2010

Abstract

Since the decrease of pH is involved in many pathological and physiological pathways, it serves as an attractive stimulus to trigger the release of a drug/gene delivery system. We report our recent approaches to the design of pH-sensitive and yet biocompatible lipids and liposomes, including lipids with an acid-labile ortho-ester linker and lipids with the trans-2-aminocyclohexanol moiety as a conformational switch of lipid tails.

Comments

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Recommended Citation

Guo, X., Samoshina, N. M., Chen, H., Brazdova, B., Franz, A. H., Zhang, H., Szoka, F. C., & Samoshin, V. V. (2010). Design of biocompatible pH-sensitive liposomes for drug and gene delivery. Paper presented at 239th American Chemical Society (ACS) National Meeting in San Francisco, CA.
https://scholarlycommons.pacific.edu/cop-facpres/330