Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations

Authors

Nataliya M. Samoshina, University of the PacificFollow
Xin Liu, University of the Pacific
Yu Zheng, University of the Pacific
Andreas H. Franz, University of the PacificFollow
Xin Guo, University of the PacificFollow
Vyacheslav V. Samoshin, University of the PacificFollow

Document Type

Poster

Department

Chemistry

Conference Title

243rd American Chemical Society (ACS) National Meeting & Exposition

Organization

American Chemical Society (ACS)

Location

San Diego, CA

Conference Dates

March 25-March 29, 2012

Date of Presentation

3-28-2012

Abstract

We suggested recently a novel type of pH-sensitive delivery system, 'fliposomes', which contain trans-2-aminocyclohexanol-based amphiphiles that perform a conformational flip and trigger an instant cargo release in acidic media. Here we report our latest studies on the cellular uptake in HeLa and B16F1 cells of the methotrexate-loaded fliposomes, which indicate that the latter can serve as viable drug delivery systems.

Comments

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Recommended Citation

Samoshina, N. M., Liu, X., Zheng, Y., Franz, A. H., Guo, X., & Samoshin, V. V. (2012). Efficient cellular delivery of methotrexate by liposomes containing novel amphiphiles with pH-triggerable conformations. Paper presented at 243rd American Chemical Society (ACS) National Meeting & Exposition in San Diego, CA.
https://scholarlycommons.pacific.edu/cop-facpres/327