ORCID

Kirkwood M. Land: 0000-0001-5951-9630

Document Type

Article

Publication Title

ACS Omega

Department

Biological Sciences

ISSN

2470-1343

Volume

3

Issue

5

DOI

10.1021/acsomega.8b00553

First Page

5808

Last Page

5813

Publication Date

5-30-2018

Abstract

In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

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