Kirkwood M. Land: 0000-0001-5951-9630
In this study, we outline the synthesis of isatin-ferrocenyl chalcone and 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates along with their antimicrobial evaluation against the human mucosal pathogen Trichomonas vaginalis. The introduction of a triazole ring among the synthesized conjugates improved the activity profiles with most of the compounds in the library, exhibiting 100% growth inhibition in a preliminary susceptibility screen at 100 μM. IC50 determination of the most potent compounds in the set revealed an inhibitory range between 2 and 13 μM. Normal flora microbiome are unaffected by these compounds, suggesting that these may be new chemical scaffolds for the discovery of new drugs against trichomonad infections.
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Cheng, L. W.,
Land, K. M.,
Synthesis and Preliminary Antimicrobial Analysis of Isatin- Ferrocene and Isatin-Ferrocenyl Chalcone Conjugates.
ACS Omega, 3(5), 5808–5813.