AldoHcy Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture
Kirkwood M. Land: 0000-0001-5951-9630
Bioorganic and Medicinal Chemistry Letters
Trypanosoma brucei and Trichomonas vaginalis are both parasitic protozoans that are known to share many similar biochemical pathways. Aristeromycin, as well as 5′-iodovinyl and 5′-oxime analogues of adenosine, are potent inhibitors of AdoHcy hydrolase in T. brucei, an enzyme that catalyses the hydrolysis of AdoHcy to adenosine and l-homocysteine. To help determine the role of this enzyme in T. vaginalis, we have tested a library of 5′-modified adenosine derivatives, including 5′-deoxy-5′-(iodomethylene)-adenosine and related 6-N-cyclopropyl analogues. Our results indicate that these inhibitors are effective at inhibiting the growth of T. vaginalis, by as much as 95%
Dornbush, P. J.,
Wnuk, S. F.,
Wrischnik, L. A.,
Land, K. M.
AldoHcy Hydrolase of Trichomonas vaginalis: Studies of the effects of 5'-deoxy-5'-(iodomethylene) adenosine and related 6-N-cyclopropyladenosine analogues on in vitro culture.
Bioorganic and Medicinal Chemistry Letters, 20(24), 7466–7468.