Food restriction lowers sympathetic support of blood pressure in aortic coarctation hypertension
J. Mark Van Ness: https://orcid.org/0000-0001-5902-8735
Health, Exercise, and Sport Sciences Department
The purpose of this study was to examine the effects of short-term food restriction on the development of aortic coarctation (AC)-induced hypertension. PC hypertension was induced in female Sprague-Dawley rats (251 ±6 g) by placing a suprarenal constricting ligature around the abdominal aorta using a blunt 21 gauge needle as a guide. Four days following AC, rats were assigned to an ad libitum fed (ADLIB; n=4) or food restricted (FR; n=5) group. FR rats received 60% of the food consumed by ADLIB rats. Following three weeks of food restriction, FR rats had significantly lower body weight (184 ±5 vs. 265 ± 5 g). Carotid and jugular catheters were implanted under halothane anaesthesia for measurement of pulsatile blood pressure and infusion of drugs in conscious rats. Food restriction resulted in a reduction in resting mean arterial pressure (145 ±9 vs. 177 ±14 mmHg), systolic blood pressure (163 ±11 vs. 213 ±22 rrmHg), diastolic blood pressure (127 ±9 vs. 147 ±9 mmHg), and heart rate (377 ±16 vs. 406 ±10 bpm) compared to ADLIB rats. There was also an attenuated depressor response to ganglionic blockade (hexamethoniunVatropine, i.V.) in FR animals (-51 ±6 vs. -88 ±5 mmHg). The cardiovascular responsiveness to graded doses of the alpha receptor agonist phenylephrine (in the ganglionic blocked rat) was not different between groups. The résulte indicate that 3 weeks of food restriction (60% of ADUB) significantly attenuates the rise in blood pressure following AC, and is accompanied by a decrease in sympathetic nervous system support of blood pressure. JMV is a Graduate Student Research Fellow, Amer. Heart Assoc., FL Affiliate.
Casto, R. M.,
Van Ness, J. M.,
Overton, J. M.
Food restriction lowers sympathetic support of blood pressure in aortic coarctation hypertension.
FASEB Journal, 10(3), 3660.