Title

Exercise capacity and immune function in male and female Chronic Fatigue Syndrome Patients

ORCID

J. Mark VanNess: https://orcid.org/0000-0001-5902-8735

Document Type

Article

Publication Title

Medicine and Science in Sports and Exercise

Department

Health, Exercise, and Sport Sciences Department

ISSN

0195-9131

Volume

36

Issue

5

Publication Date

1-1-2004

Abstract

Hyperactivition of an unwanted cellular cascade by the immune-related protein RNase L has been linked to reduced exercise capacity in persons with chronic fatigue syndrome (CFS). This investigation compares exercise capacities of CFS patients with deregulation of the RNase L pathway and CFS patients with normal regulation, while controlling for potentially confounding gender effects. Thirtyfive male and seventy-one female CFS patients performed graded exercise tests to voluntary exhaustion. Measures of peak VO2, peak heart rate, body mass index, perceived exertion, and respiratory quotient were entered into a two-way factorial analysis with gender and immune status as independent variables. A significant multivariate main effect was found for immune status (p<0.01), with no gender effect or interaction. Follow-up analyses identified VO2 peak as contributing most to the difference. These results implicate abnormal immune activity in the pathology of exercise intolerance in CFS and are consistent with a channelopathy involving oxidative stress and nitric oxide-related toxicity

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