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Date of Award
2009
Document Type
Thesis - Pacific Access Restricted
Degree Name
Master of Science (M.S.)
Department
Pharmaceutical and Chemical Sciences
First Advisor
Roshanak Rahimian
First Committee Member
Timothy Smith
Second Committee Member
David Thomas
Abstract
Objectives: To date little is known of the interaction between diabetes and sex hormones in the vasculature. A number of studies suggest that premenopausal diabetic women loose their gender based cardiovascular protection. However, there is insufficient evidence to explain the mechanism underlying the loss of this gender based cardioprotection in premenopausal diabetic women. The objectives of this study were to investigate whether there is a gender difference in the aortic endothelial function in · streptozotocin (STZ, 58 mg/kg, iv)-induced diabetic rats, and the potential role of superoxide and cyclooxygenase (COX) metabolites in diabetes-induced vascular dysfunction.
Pages
92
Recommended Citation
Kekatpure, Avantika. (2009). Gender differences in aortic endothelial function in a rat model of streptozotocin-induced diabetes : possible role of superoxide and cyclooxygenase. University of the Pacific, Thesis - Pacific Access Restricted. https://scholarlycommons.pacific.edu/uop_etds/737
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