Title

Effects of Rutaecarpine on the Pharmacokinetics of Caffeine in Rats

Poster Number

17

Lead Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Lead Author Status

Masters Student

Second Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Second Author Status

Faculty

Third Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Third Author Status

Faculty

Fourth Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Fourth Author Status

Faculty

Fifth Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Fifth Author Status

Doctoral Student

Sixth Author Affiliation

Department of Pharmaceutics and Medicinal Chemistry

Sixth Author Status

Doctoral Student

Additional Authors

Department of Pharmaceutics and Medicinal Chemistry, Master student

Introduction

Rutaecarpine, a pentacyclic indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, has been reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to speed up the removal of caffeine (CYP1A2 substrate) from blood.

Location

DUC Ballroom A&B

Format

Poster Presentation

Poster Session

Afternoon

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Apr 29th, 1:00 PM Apr 29th, 3:00 PM

Effects of Rutaecarpine on the Pharmacokinetics of Caffeine in Rats

DUC Ballroom A&B

Rutaecarpine, a pentacyclic indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, has been reported as a potent inducer of CYP1A2 enzyme in rats. There are natural herbal supplements containing rutaecarpine that are designed to speed up the removal of caffeine (CYP1A2 substrate) from blood.